Argireline Skin Serum Review

Argireline is a new beauty serum ingredient used by a growing number of manufacturers. Find out if argireline actually works as promised today in our review or poses as a serious side effect risk if used too frequently?

What is Argireline?

Argireline is a chemical compound that is officially known by the less catchy name acetyl hexapeptide-3. In an effort to better market the chemical compound to consumers, beauty product manufacturers call the compound Argireline.

Chemically speaking, Argireline is a peptide. The chemical compound is assembled in laboratories, which makes it a synthetic beauty ingredient. The peptide itself is a fragment of SNAP-25. You’ve probably never heard of SNAP-25, but you have heard of Botox: SNAP-25 is a substrate of Botulinum toxin, better known as Botox.

Basically, Argireline promises to be a topical chemical compound that can be rubbed into your skin to give you Botox-like results without injections.

Argireline is a relatively new beauty compound and its research has not been extensively published. We know the results of certain in vitro tests (tests performed outside of living organisms) and in vivo tests (tests performed on a living organism), but the results of double blind clinical studies have not yet been released.

How Does Argireline Work?

Argireline works in a similar way to Botox.

First, you apply Argireline onto your skin. It’s typically included as part of an anti-aging serum and it may be mixed with other ingredients.

After applying Argireline, it will gradually be absorbed into your skin.

Once it’s been absorbed, Argireline inhibits the reactions that cause facial muscles to move or contract. When you smile or frown, for example, your facial muscles are less likely to crease along your wrinkle lines.

By applying Argireline consistently over a long period of time, you can dramatically reduce the formation of wrinkles on your face – especially in problem spots like your forehead and around your eyes.

So how exactly does Argireline “freeze” your skin in place? The secret to Argireline lies in its peptides. Peptides are just chains of amino acids. When these amino acids enter your skin cells, it inhibits the responses of your facial muscles, which means they contract with less force.

Here’s how the manufacturer of Argireline, Lipotec, describes the actions of the compound:

“This hexapeptide mimics the N-terminal end of SNAP-25 and competes with this natural protein for a position in the SNARE complex. As a result, neurotransmitters are note released efficiently and facial contractions are weakened and muscles relaxed, thus inhibiting the formation of wrinkles.”

According to that manufacturer, this method of action reduces the depth of wrinkles by 17% in 15 days and smoothes out the face.

Botox Versus Argireline

Argireline is basically a weaker version of Botox. The two serums are derived from the same ingredients and target the same processes within your skin.

The main difference between the effectiveness of Botox and the effectiveness of Argireline is that Argireline penetrates into your skin at a shallower level than Botox. Obviously, Botox relies on injections which can penetrate deep into the lower layers of your skin, while Argireline relies on topical applications.

That means Argireline will inevitably be less effective than Botox – but that’s true when comparing most injection products versus topical products.

How to Buy Argireline

Argireline-based beauty products can be found at many retail outlets and online stores. There’s no real secret to buying these products: just look for Argireline mentioned on the label.

Beauty product manufacturers are happy to advertise Argireline so any products that include Argireline will be prominently advertised as such.

Ideally, the Argireline product you choose will have a concentration of 10% or higher. No beauty product we’ve found has a higher concentration than 20% Argireline.

At the time of writing, one Argireline anti-aging serum was being sold on Amazon for $18.95 for a 1 fluid ounce (30mL) bottle. That serum contains 20% argireline.

Controversy About Argireline

Because Argireline is a relatively new ingredient, there’s still some controversy over how it works or even if it works as advertised.

The biggest problem with Argireline is that the results of its double-blind placebo-controlled clinical studies have not yet been published.

As a result, we only have anecdotal reports of Argireline’s effectiveness.

Some anecdotal reports claim that Argireline makes your skin sag with long term use, for example. One commenter on also claims that Argireline “might also affect brain receptors and cause brain fuzz.”

Another reviewer who claims to be a genetic scientist claims that the chemical compound for Argireline is harmless:

“Speaking from a research pov, I can't see anything wrong with the chemical… No, your skin won't be damaged when using Argireline-based products…yes it'll reduce wrinkles…no it is not an “anti” aging cream…”

Until we have more concrete, scientifically-verified evidence for Argireline, it’s going to be difficult to say how effective it is.

Who Makes Argireline?

Argireline is a registered trademark formula created by a company called Lipotec. In order to use Argireline, you’ll need to license the chemical compound from Lipotec (email [email protected] for more information).

Argireline’s sales page can be found here. At that sales page, you’ll see marketing demonstrations and other official information about Argireline.

Lipotec itself is based at the following address in Spain:

Lipotec SAU
Isaac Peral, 17 Pol. Ind. Camí Ral
08850 Barcelona · Spain

You can reach the company by phone at (+34) 936388000 or at (+34) 935453257.

Lipotec is a subsidiary of Lubrizol, a Berkshire Hathaway company that describes itself as a “leader in specialty chemicals”.

We’ll update this article when more information about Argireline and its scientifically-demonstrated benefits becomes available to the public.


  1. When was this written? It says Argireline is “relatively new” and I have been using it since the mid 90’s and have never experienced brain fuzz or fog from it. Also, those concentrations are too high. 5% is optimal.


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