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Methylene Blue Review

Methylene Blue is a new nootropic compound currently being studied as a potential cure for Alzheimer’s by a company called TauRx.

Find out if Methylene Blue is the real deal today in our review.

What is Methylene Blue?

Methylene blue is a chemical compound that is thought to work by creating enzymatic effects in the brain.

Prior to being used as a “brain drug”, methylene blue was actually used as a dye in diagnostic applications, which is where the “blue” part of the name comes from. Researchers eventually discovered that methylene blue can also act as a potent, reversible monoamine oxidase inhibitor, which could make it an ideal treatment for various neurological conditions.

The chemical itself is officially called methylthioninium chloride.

Methylene blue goes to work and specifically improves three aspects of brain functionality, including:

— Acts as a potent, self-regenerating antioxidant that can easily cross the blood-brain barrier

— Improves the efficiency of mitochondria, which are the powerhouses of the cells and responsible for physical and mental energy

— Normalize the activity of an enzyme called Monoamine Oxidase A that increases in prevalence with aging and is associated with depression

Together, these three unique benefits have made methylene blue one of the most sought-after nootropic compounds on the market today.

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Scientific Studies on Methylene Blue

A search for methylene blue on PubMed.gov reveals 14,546 studies on the chemical compound. In 2006, there were 359 studies published on methylene blue. In 2014, that number rose to 741. The number of studies performed so far in 2015 is on pace to break 2014’s record.

Here are some of the most significant studies on methylene blue performed to date:

2011 Study Shows Methylene Blue May Be Able to Treat Dementia After It’s Already Appeared

One study from 2011 analyzed an alternative form of methylene blue created by TauRx Therapeutics. That alternative form, called LMTX, was designed to combat some of the complaints of the original Rember formula. Researchers found that LMTX was effective at delaying the advance of dementia after dementia has already been diagnosed.

This is important because other modern treatments – including antioxidants and mitochondrial antioxidants – only work prior to the onset of dementia. LMTX could potentially treat the disease after it’s already been diagnosed.

Researchers concluded that the study was an overwhelming success:

“Ultimately, although the majority of therapeutics will require a long process of clinical development, the overall successes described in this review indicate that an effective prevention treatment or cure for AD [Alzheimer’s Disease] is possible.”

2011 Study Indicates that Methylene Blue Works By Inhibiting Tau Protein Aggregation

Tau protein is one term that frequently appears in methylene blue studies. That’s because in a 2011 study, researchers demonstrated that methylene blue works by inhibiting Tau protein aggregation. It also has a “great effect” on the dissociation of amyloids while affecting mitochondrial function as well. Together, these mechanisms are thought to delay the progression of Alzheimer’s, Parkinson’s dementia, and other degenerative neurological conditions.

2007 Study Shows Methylene Blue Can Extend the Lifespan of Certain Cells

One landmark study on methylene took place in 2007. That study showed that methylene blue, referred to as MB in this study, can increase the lifespan of cells:

“MB increases mitochondrial complex IV by 30%, enhances cellular oxygen consumption by 37–70%, increases heme synthesis, and reverses premature senescence caused by H2O2 or cadmium.”

If you don’t know what “complex IV” is, then that’s okay. The most important thing you need to know about it is that lower mitochondrial complex IV levels are associated with worsening Alzheimer’s conditions.

Methylene blue has been shown to increase mitochondrial complex IV, which is an important benefit on its own. Methylene blue is particularly beneficial because it increase mitochondrial complex IV while also boosting oxygen consumption in the cells and reversing premature senescence. Together, these benefits extend the lifespan of cells in your body.

Researchers concluded the study by stating that:

“MB may be useful to delay mitochondrial dysfunction with aging and the decrease in complex IV in Alzheimer disease.”

More studies are being performed on methylene blue every month. As researchers learn more and more about methylene blue and its benefits, it’s getting closer to reaching the market and becoming a publically-available drug.

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