Protandim Nrf1 Synergizer Review
Protandim Nrf1 Synergizer is a new nutritional supplement that promises to help tune your cells at the genetic level in order to regulate the aging process. Let’s find out more about how Protandim works today in our review.
What is Protandim NRF1 Synergizer?
Protandim Nrf1 Synergizer is a nutritional supplement made by LifeVantage, a multilevel marketing company that sells a number of other nutritional supplements.
Protandim claims to relieve oxidative stress on the body by flooding your body with antioxidants.
The supplement will launch in Q4 2016 during a live broadcast that will take place around the world. The Nrf1 Synergizer is expected to work in a similar way to LifeVantage’s other nutritional supplement, the Nrf2 Synergizer (yes, the company released the Nrf2 Synergizer first and is releasing the Nrf1 Synergizer second).
The supplements are called Nrf1/Nrf2 Synergizers because Nrf2 is a protein that binds itself to a DNA sequence:
“Nrf2 enters cells to stimulate protective genes and enzymes to neutralize the effects of free radicals”.
The Protandim NRF1 Synergizer launch was announced on February 19 during LifeVantage’s Elite Academy in Nashville, Tennessee.
How Does Protandim NRF1 Synergizer Work?
Protandim Nrf1 Synergizer claims to work in tandem with the original Protandim Nrf2 Synergizer. In a press release, LifeVantage President and Chief Executive Officer, Darren Jensen, had this to say about how the supplement works:
“The Protandim NFR1 Synergizer is formulated to strengthen the mitochondria, which are the power house of all cells for better cellular health. It is designed to work in tandem with our flagship Protandim Nrf2 Synergizer product and further enhance our body's ability to naturally produce antioxidants and reduce the effects of cellular stress on its own.”
So far, all we really know about the Nrf1 Synergizer is that it will be launched worldwide sometime in Q4 2016. We don’t know any further details about how it works, which ingredients are included, or how many clinical tests have taken place (if any).
Fortunately, we do know how the original Protandim supplement, the Nrf2 Synergizer, claims to work. That supplement uses ingredients like:
Together, these ingredients claim to flood your body with valuable antioxidants. Antioxidants are special molecules that target free radicals in your body, relieving oxidative stress. They’re found naturally in a number of fruits, for example, and many people take supplements to ensure they get sufficient antioxidants every day.
The Protandim lineup takes this a step further by actually claiming that these ingredients active the Nrf2 protein. As mentioned above, Nrf2 is a protein that binds itself to your DNA. By activating this protein, Protandim claims to regulate survival genes and reduce oxidative stress even further.
Scientific Evidence for Protandim
LifeVantage frequently mentions that it’s a science-based company committed to making supplements backed by extensive scientific evidence.
So what does the science behind Protandim say?
LifeVantage dedicates a page of their site to discussing the science behind the supplement. That page mentions how Dr. Joe McCord, a “world-renowned scientist and pioneer in free radical biology”, created Protandim after devoting his life to the study of free radicals. Dr. McCord is listed as the “former LifeVantage Chief Science Officer”, so it seems like he no longer works for the company.
Dr. McCord and his team cite three studies that have been performed on Nrf2 Synergizer over the years. Those studies include:
Ex Vivo Study Shows Protandim Has Protective Effect
One study published in Free Radical Biology and Medicine in March 2011 showed that the antioxidants in Protandim can have a protective effect.
Researchers specifically examined the effect that Protandim had on human saphenous veins, or HSVs, which are widely used for bypass grafts. Researchers concluded by stating that:
“Results showed that HSV cultured ex vivo exhibit an ~ 3-fold increase in proliferation and ~ 3.6-fold increase in intimal area relative to freshly isolated HSV. Treatment of HSV during culture with Protandim, a nutritional supplement known to activate Nrf2 and increase the expression of antioxidant enzymes in several in vitro and in vivo models, blocks IH and reduces cellular proliferation to that of freshly isolated HSV. Protandim treatment increased the activity of SOD, HO-1, and catalase 3-, 7-, and 12-fold, respectively, and decreased the levels of superoxide (O2•−) and the lipid peroxidation product 4-HNE.”
Basically, Protandim was tested on human tissue outside of the human body (“ex vivo”), where it showed an ability to reduce oxidative stress in that tissue, reducing cellular proliferation while increasing the activity of certain molecules.
In other words, Protandim was observed to have a protective effect in this study.
2010 Study Shows Protandim May Reduce Oxidative Stress in Mice
A study published in 2010 in the Journal of Dietary Supplements involved testing Protandim on mice.
Researchers tested the supplement on mice to gauge the effect the supplement might have on humans with muscular dystrophy. Oxidative damage has often been suggested as one of the major causes of muscular dystrophy.
Researchers took a group of 3 week old mice and separated them into two treatment groups. One group received normal mouse food while the other group took mouse food with Protandim added in.
The mice received the diet for 6 months, during which researchers tested their oxidative stress. The Protandim food mix in mice was observed to be safe and well-tolerated for a period of six months.
Researchers also observed that the mice eating the Protandim food experienced a 48% average decrease in plasma thiobarbituric acid-reactive substances (TBARS) as well as positive movement in a number of other oxidative stress indicators, like 38% less MRI signal abnormality.
After the six month period, the mice that took Protandim did not significantly alter motor function nor histological criteria.
So mice were observed to have lower levels of oxidative stress in their system after being treated with Protandim. The supplement was also safe and well-tolerated with no serious complications reported.
2009 Study Shows Protandim Can Boost Heart Health
A 2009 study published in Circulation examined the effects of Protandim on heart health. Researchers were studying the relationship between right ventricular (RV) function and pulmonary arterial hypertension.
To do that, researchers took a “mechanical animal model” and compared it to an established model. Then, they added a dietary supplement, Protandim, that was observed to prevent fibrosis and capillary loss and preserve RV function “despite continuing pressure overload”.
In other words, Protandim was shown to decrease pressure in the heart, which could reduce the risk of heart attack.
There are some problems with all of these studies. The first and most glaring problem is that none of them have taken place on human subjects. The 2009 study used a mechanical animal model, for example, while later studies used mice and ex vivo human tissue.
The other problem is that there are only three listed studies.
Fortunately, LifeVantage claims that more Protandim studies are on the way – although it hasn’t mentioned whether or not human clinical trials have taken place.
Since the Nrf1 Synergizer has not yet been released, we haven’t yet seen any studies specifically on it.
It’s always a good idea to wait for reliable research to come out before you start taking a nutritional supplement. With LifeVantage’s Protandim Nrf2 and Nrf1 Synergizers, we haven’t yet seen that research.
Protandim Nrf1 Synergizer Pricing
Protandim Nrf1 Synergizer has not yet been released, so we don’t know the pricing details for the upcoming supplement.
The original Protandim Nrf2 Synergizer, however, is exclusively available through LifeVantage distributors. These distributors sell Protandim directly to consumers and prices are not typically listed online.
However, a quick Google Search shows us that LifeVantage network members are selling products through eBay and other third party retailers, where pricing looks like this:
— 1 Bottle (30 Capsules): $40.49 USD
You may find cheaper prices, but that appears to be the approximate price at which most LifeVantage distributors are selling.
LifeVantage tells you to take one caplet per day, so one bottle lasts for a month. Each caplet contains 675mg of a proprietary formula.
It’s expected that the Nrf1 Synergizer will offer similar pricing to the original supplement.
LifeVantage Corporation is a publically-traded (Nasdaq:LFVN) multi-level marketing company that claims to take a science-based approach to making nutritional supplements and promises to “transform health, wellness and anti-aging internally and externally at the cellular level.”
In addition to the popular Nrf2 Synergizer (and the upcoming Nrf1 Synergizer), the company makes supplements like TrueScience Anti-Aging Skin Care Regimen, Canine Health, the AXIO energy product line and the PhysIQ Smart Weight Management System.
The company was founded in 2003 and is headquartered in Salt Lake City, Utah.
Should You Use Protandim Nrf1 Synergizer?
Protandim Nrf1 Synergizer is a nutritional supplement preparing for launch in Q4 2016. So far, neither Protandim Nrf1 Synergizer or the original supplement, the Nrf2 Synergizer, have been tested in humans in any major studies – they’ve only been tested in mice and on ex vivo human tissue, where they showed modest antioxidative effects.
Until more reliable research on real human subjects is conducted, it’s impossible to verify the claims made by LifeVantage. In any case, you shouldn’t take any supplement or medicine that has never been tested on humans in major clinical studies.