Nucific Review

Nucific Review

Nucific is a nutritional supplement manufacturer that sells two weight loss products: BIO X4 and CL X3. Here’s our Nucific review.

What is Nucific?

Nucific is a nutritional supplement manufacturer and retailer based in Tarzana, California. The company currently sells just two nutritional supplements, BIO X4 and CL X3.

All Nucific products are available for sale online at the company’s official website, Purchases come with a 90 day refund policy.

Nucific Products

Nucific sells two products:

Nucific BIO X4

Nucific BIO X4 calls itself a “revolutionary new compound” that contains 4 proven ingredients to help you manage your weight. Those four proven ingredients work by suppressing your appetite, supporting digestive health, and supporting weight loss management.

The four magical ingredients include 13 billion colony forming units (CFUs) of probiotic bacteria. Probiotics are beneficial bacteria that live in your gut and help you break down food more efficiently.

In some sources, you’ll see 39 billion CFUs advertised. That’s the number of CFUs you get when you take three BIO X4 capsules (the recommended daily dosage). There are 90 capsules in each container.

Other ingredients include green tea, Caralluma Fimbriata Extract, and a digestive enzyme blend containing amylase and bromelain.

The supplement is priced at the following rates:

— 1 Bottle (30 Day Supply): $49
— 3 Bottles (90 Day Supply): $129
— 6 Bottles (180 Day Supply): $240

All orders over $50 come with free shipping and include a 90 day refund policy.

Nucific CL X3

Nucific’s CL X3, on the other hand, is a safflower-derived supplement that is primarily used as a weight loss tool. Its key benefits include body fat reduction and reduced appetite.

CL X3’s most active ingredient is conjugated linoleic acid (CLA). That fatty acid is derived from safflower and, according to Nucific, is “proven to lower appetite” while also stimulating the breakdown of fat and preventing your body from storing fat. Other key ingredients include fucoxanthin (brown seaweed extract), and grapefruit seed extract.

You can buy Nucific CL X3 for:

— 1 Bottle (30 Day Supply): $47
— 3 Bottles (90 Day Supply): $123
— 6 Bottles (180 Day Supply): $228

Once again, free shipping is available on orders over $50 and there is a 90 day money back guarantee.

Scientific Evidence for Nucific Products

Nucific claims that all its products are backed by significant scientific evidence. Nevertheless, very little scientific evidence is available on the official website. The company tosses around terms like “potent ingredients”, “quality tested”, and “earth friendly” without linking to any major clinical or scientific studies on their supplements.

If you Google search the ingredients in Nucific, however, you’ll find some evidence for the weight loss effects of Nucific BIO X4 and CL X3.

BIO X4 Scientific Evidence

The probiotics in BIO X4 are a well-established way to treat irritable bowel syndrome and boost the health of your immune system. There are mountains of clinical and scientific studies supporting this claim online.

However, with Nucific BIO X4, it’s important to recognize that there are just 13 billion CFUs in each pill. That’s a below average number of CFUs for the probiotics industry, where capsules can contain anywhere from 20 to 100 billion CFUs.

The other key ingredient in BIO X4 is the enzyme blend that primarily contains amylase and bromelain, both of which purportedly help you lose weight by hydrolyzing your fat. did a good writeup on the benefits of amylase and found that there was limited evidence for any of these weight loss benefits. Amylase has, however, been shown to successfully reduce muscle soreness and osteoarthritis.

Out of all the ingredients in BIO X4, green tea is the one backed by the most scientific evidence. Green tea – specifically green tea’s active ingredient, Epigallocatechin gallate (EGCG) has been shown to provide a wide range of benefits, including weight loss, better metabolism, and overall elevated energy levels.

The final ingredient in BIO X4 is Caralluma Fimbriata Extract, which has been studied primarily for its weight loss properties by reducing appetite and boosting metabolism. There are two linked studies from 2007 and from 2013 that show positive results.

Based on this evidence, it appears that BIO X4 is more of a green tea-based probiotic than a powerful weight management pill.

CL X3 Scientific Evidence

CL X3’s scientific evidence is a little more concrete. CLA has been linked to a number of weight loss results in recent years and is growing rapidly in popularity across the weight loss community (which is why companies like Nucific have released CLA supplements in 2015). published a report discussing how 1000mg of CLA can have a significant impact on your weight loss results. In one double blind study, participants took three doses of CLA every day for 12 weeks. By the end of the study, the group that took CLA lost more weight on average and had healthier HDL (cholesterol) levels. Researchers determined that participants’ bodies used the free fatty acids as a fuel source from the breakdown of fat cells due to actions caused by CLA. Basically, if you have more free fatty acids in your blood while you are exercising, your body will burn more fat while exercising.

Fucoxanthin is also thought to be the world’s best source of antioxidants. Although there is only 50mg of fucoxanthin extract inside each capsule of CL X3, it can still help target free radicals within your body and reduce the risk of disease.

How to Buy Nucific Supplements

Nucific is currently only available from, where it’s priced at the levels listed above ($49 per bottle of Bio X4 and $47 per bottle of CL X3).

Free shipping is offered on all orders over $50, so you’ll need to order at least two bottles of either supplement (or mix and match) in order to qualify for free shipping.

Shipping costs $4.95 per order anywhere in the United States.

You can pay using the secure online form at the official site, which accepts payments by all major credit cards and through PayPal.

All orders come with a 90 day money back guarantee. Call 888-679-5520 or email [email protected] to get in touch with the company’s customer support team.

About Nucific

Nucific is a California-based supplement company that also claims to manufacture its supplements in California (although it appears to source its ingredients from around the world).

The company’s headquarters can be found at:

19528 Ventura Blvd. #343
Tarzana, CA 91356


  1. I’ve been taking BIO.X4 for about 2 weeks and have lost about 1.5″ on my waist but have gained 10 lbs. If anything I have been eating less. How long do I have to wait before I start to loose weight?

    • If your losing inches but gaining weight it’s probably the addition of muscle. Muscle is more dense the fat so it weighs more than fat. Losing inches is a lot more meaningful than losing weight. Also the more muscle you have the faster your metabolism works. Congrats on the reduced waist line!!

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