Clomiphene Review – SERM Estrogen Blocker For Boosting Testosterone?

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5 Fast Facts You Need to Know About Clomiphene

Clomiphene has been in the news lately after Brock Lesnar and Jon Jones tested positive for the substance at UFC 200.

Today, we’re listing the most important things you need to know about this steroid-like substance.

Yes, Brock Lesnar and Jon Jones (Allegedly) Took Clomiphene

Brock Lesnar may be one of the scariest human beings on the planet. Typically, 39 year old fathers of four don’t clock in at 6’3”, 286 pounds of muscle. They also don’t have NCAA champion-level wrestling ability.

Lesnar may claim that his secret is training hard at his farm in Saskatchewan. But in reality, Brock Lesnar reportedly tested positive for the same substance as Jon Jones prior to UFC 200.

Both Lesnar and Jones reportedly tested positive for the popular estrogen blocker, clomiphene. That’s a substance typically used to block estrogen and mask steroid use. It can also stimulate natural testosterone production while limiting the unwanted physical side effects that come from steroid use.

In layman’s terms, it’s the type of steroid-like substance you use if you don’t want to get caught using steroids.

Sherdog.com reports that Lesnar tested positive for clomiphene twice: first, in an out-of-competition test on June 28 as well as an in-competition test given at UFC 200. The news was first broken by LA Times reporters.

Jon Jones, on the other hand, was famously pulled from UFC 200 after it was revealed that he had tested positive for two types of performance-enhancing drugs, one of which was clomiphene. Jones’ former training partner and title challenger Rashad Evans was the first to claim that Jones had tested positive for clomiphene. The USADA later reported that he was correct.

The other substance Jones tested positive for, by the way, was testosterone booster letrozole.

Lesnar ended up winning a $2.5 million purse for his unanimous decision victory over Mark Hunt on July 9 at the T-Mobile Arena in Las Vegas, winning his first UFC fight since December 2011. However, he faces a possible two year suspension for the anti-doping violation (although many people believe it was Lesnar’s last UFC fight anyway).

Jones, however, will likely want to return to the ring at some point in the near future. It’s unclear what his PED punishment might be.

The USADA website reports that Lesnar submitted 8 samples since he first announced his intention to return to the UFC. Prior to getting popped on June 28, the former NCAA wrestling champion had reportedly submitted multiple clean samples.

Jones, by the way, blamed the positive test on tainted supplements.

So what exactly is Clomiphene? Let’s take a closer look.

How Does Clomiphene Work?

Clomiphene, for the purposes of this article, is a performance-enhancing drug. The LA Times reports that it can increase testosterone by 50%. Although we know it as a PED, the drug is officially classified as a fertility drug.

Typically, when used for PED purposes, clomiphene is used in conjunction with a substance like letrozole (the other substance for which Jones tested positive). The pair stack well together. Here’s how one LA Times source reported it:

“The [letrozole] blocks conversion of testosterone to estrogen … making you stronger, faster and aiding your recovery [between workouts]. … It’d be like increasing the amount of water going into a bathtub with [clomiphene] and reducing the size of the drain with the [letrozole]. The effect is more water in the bathtub —more testosterone. The drugs are synergistic.”

What Exactly Is Clomiphene?

Clomiphene is a fertility drug that goes by a variety of different names, including Clomifene or Clomiphene in the United States. It’s also trademarked as Androxal, Clomid, and Omifin, or as citrate salt Serophene.

The compound works as a selective estrogen receptor modulator (SERM), not to be confused with SARM. Although the drug has been mostly in headlines for enhancing the performance of professional athletes, it’s also the world’s most widely-prescribed drug to induce ovulation to reverse anovulation or oligoovulation.

Widespread evidence supporting the use of clomiphene for fertility is lacking. However, some studies have shown that the clinical pregnancy rate with clomiphene treatment is 5.6% per cycle versus 1.3% to 4.2% per cycle without treatment.

Side Effects of Clomiphene

Clomiphene, like most substances that affect hormone levels in your body, can lead to some serious and unwanted side effects.

1 to 10% of users, for example, report visual side effects like blurred vision, double vision, floaters, sensitivity to light, headaches, hot flashes, abnormal uterine bleeding, and abdominal discomfort.

In less than 1% of users, it can also lead to higher blood levels of triglycerides, inflammation of the liver, and reversible baldness.

Some studies have suggested that prolonged use of clomiphene for over a year can lead to an increased risk of ovarian cancer.

How to Buy Clomiphene

Clomiphene is legally only available through a prescription from your doctor.

Since the drug is typically prescribed to treat male or female infertility, you’re not going to have much luck walking up to your doctor and saying something like, “I want to get bigger and stronger so I can fight better at UFC 202.”

There are the usual semi-legal sources for clomiphene online, many of which advertise the substance as Clomid. I’m not going to link to these marketplaces, as they’re typically illegal or at the very least a grey area. However, one website we found was charged about $1.50 USD per pill, with that price dropping to as little as $1 per pill the more you purchased (for 100mg pills). You can also purchase Clomid in 25mg or 50mg varieties.

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