There are many products on the market that claim to have the capabilities to boost cognitive functions and brain activity. However, the chemical makeup of most of these products is questionable and deciding which one to use can be a rather difficult choice to make.
Although most of these products make bold claims that more often than not have been proven to be ineffective, there are some products that contain a certain polyphenol antioxidant by the name of pterostilbene which can be very beneficial for not only your brain but also the rest of your body.
What is Pterostilbene?
Pterostilbene is a substance which is produced by plant tissues in order to fight insect infestations, ultraviolet light exposure, heat, and infections.
Pterostilbene belongs to the same family as resveratrol, and both are a phenolic compound found in small quantities in foods such as grapes, blueberries, cranberries, and pterocarpus marsupium (also known as the Indian kino tree).
Although both resveratrol and pterostilbene are capable of delivering amazing benefits for your bodies, pterostilbene is more bioavailable than resveratrol, meaning it is less likely to be eliminated by your body as waste and more likely to have a lasting effect on your body.
Pterostilbene has been gaining a lot of ground in the nootropics community for its ability to help with a variety of issues such as brain inflammations, cognitive decline, and brain cell degenerations. It has been known to boost dopamine levels in the brain, as well.
Since there are so many different levels of impact that pterostilbene has on your brain and its functionality, it has been determined to improve your learning capabilities and your memory in a few different ways.
It increases neuroplasticity in the hippocampus, is a fantastic neuroprotectant, and can elevate brain-derived neurotrophic factor (BDNF).
What exactly does Pterostilbene do to your brain?
There are a few different ways that pterostilbene acts on your brain, but the two most common ways are the mimicry of calorie restriction and the boosting of dopamine.
When you reduce your calorie intake, your body responds to it in a specific way. Besides losing weight, it also improves your cholesterol levels, your blood pressure, and the ability to control glucose more effectively.
Even decreasing your calorie intake for a short amount of time has shown to increase your insulin sensitivity and improve your core body temperature, both of which are markers for longevity.
Many researchers have also shown that reducing calorie intake can improve systematic inflammation, which can be the leading cause of many degenerative and chronic diseases.
Essentially, if you decrease your calorie intake, your body will be stimulated in such a way that you will be adding years to your lifespan. Pterostilbene has the ability to mimic the same effects that your body produces when you decrease your calorie intake.
It can do all of this without significantly modifying your diet. More specifically, pterostilbene mimics the favorable impact that calorie intake reduction has on your genes that influence the process of aging.
Since pterostilbene is such a potent antioxidant, it increases your brain’s dopamine levels, but it doesn’t do so directly. The way that dopamine levels are boosted with the help of pterostilbene is rather interesting.
We know that neural degeneration is primarily caused by high oxidative stress, and luckily pterostilbene and its anti-oxidant properties can counteract and even reverse damage to your neurons, which means that the production of dopamine can be increased since your neurons are functioning properly and are not hindered by neural degeneration.
Increased levels of dopamine result in increased movement, better memory, better behavior and cognition, ability to pay attention, more enjoyable sleep, better mood, and increased levels of learning.
What happens to your brain with age?
As you age, your brain changes chemically and metabolically. These changes cause a few things to happen. Neural and synapse degeneration is one of them. As you age, cellular stress causes the neurons in your brain to wear out and become less effective at their job.
A similar thing happens to your synapse, and they wear out and eventually lose connections. At first, this doesn’t have much of an effect on your brain because your brain is designed to reroute around the dead patches.
But over time, the more neurons and synapses become damaged the more prominent and visible the effects become. Your ability to recall memory becomes hindered and nearly impossible. Reaction time is also affected. Your overall memory is diminished as well as your general mood.
As time progresses, the levels of neurotransmitters also start to decline, which can have many effects on your body and your mental state. Oxidation starts to damage your brain cells and your cognitive functions degenerate.
Your levels of anxiety can also become increased. All of these changes that are related to age can become contributing factors to degenerative diseases such as Parkinson’s and Alzheimer’s.
How does Pterostilbene counteract the effects of aging?
Pterostilbene doesn’t function the same way that most other nootropics do. It helps to improve your memory and adds additional neuroprotection through other methods than most common nootropics.
PTE mostly works through gene expression, essentially influencing genes which produce proteins for certain purposes. So in a way, pterostilbene modulates genes which influence mitochondria and even cell DNA.
Apoptosis is also something that pterostilbene can simulate, which results in the production of new healthy cells and also reduces the likelihood that some cells will be invaded by cancer.
Apoptosis is essentially a process of programmed cell death. When pterostilbene simulates apoptosis, it causes some of our cells to die. This is not necessarily a bad thing considering our cells are constantly going through a process of morphology.
When they die, room is made for new cells to develop and take their place. As mentioned above, this can be a good thing since some cells can be invaded by cancer and other degenerative diseases.
Although pterostilbene is very similar to resveratrol, one should not make the mistake, like some supplement companies have done, of thinking that pterostilbene is the upgraded or better version of Resveratrol.
This common misconception is most likely due to the bio-viability of PTE, which is about sixty percent higher than that of Resveratrol. Many researchers have proven that PTE works very well alongside Resveratrol, not instead of it.
Resveratrol functions at the start of the flow of neurochemical events which activates genes resulting in cognitive benefits, while PTE provides its gene expression effects at the end of the molecular stream. This means that together the two complement each other very well.
Instead of delivering extra levels of dopamine to your brain like some other nootropics, pterostilbene functions in a different way. It prevents the dopamine which is already in your brain from being used up by other means.
This is slightly similar to the way Ritalin functions as a stimulant. Essentially, higher levels of dopamine are reserved for brain functions directed towards memory and cognativity by reducing the amount of dopamine which is used by other neuroreceptors, resulting in better brain activity.
Can Pterostilbene reduce anxiety?
Recent research in mice has shown that Pterostilbene demonstrates anxiolytic-type functions through down-regulation of phosphorylated levels of extracellular regulated kinases in their hippocampus.
A team of researchers gave a dosage of Pterostilbene to their mice and measured the levels extracellular regulated kinase one and extracellular regulated kinase two.
ERK1 and ERK2 are known to have an effect on mood modulation in both animals and humans. Analysis showed that both ERK1 and ERK2 levels were decreased in mice which took the dosage of 1mg and 2mg.
Furthermore, the mobility and motor functions of the mice were not impaired. This suggests a positive index of safety for the compound. All of this means that Pterostilbene has the potential to treat anxiety disorders.
How much Pterostilbene should I take?
The recommended daily dosage of Pterostilbene is 50mg. The standalone supplement is rather difficult to find in your local pharmacy but should be easily obtainable through online retailers.
Even in smaller doses, Pterostilbene can provide many of its known benefits. If you prefer to stick with getting Pterostilbene out of plants and foods, then you should consider blueberries as a primary source. Even though a cup of blueberries contains only about 20mcg of Pterostilbene, it is still enough to see some of the benefits it offers.
What about the side effects of Pterostilbene?
There are no known side-effects associated with Pterostilbene. After taking the supplement or increasing direct Pterostilbene intake, you will have more energy and start thinking with clarity and speed. T
he Pterostilbene supplements should be well tolerated by most people. In fact, there was a study done to measure the side-effects and possible conditions that might develop due to increased intake of Pterostilbene which concluded that it should be safe to take up to 250mg daily.
Keep in mind that even though the safe dose is up to 250mg, this doesn’t mean that taking more Pterostilbene will result in higher levels of benefits. The optimal dosage is 50mg, and anything higher than that won’t result in better benefit levels.
Which Pterostilbene supplements should you take?
Now that you know all of the benefits to taking Pterostilbene, you must be wondering which Pterostilbene supplements are best for you. This can be a tricky question to answer but we can definitely help.
We looked through a variety of different supplements out there and read some reviews while comparing prices and quantities. After some careful consideration, here are our top suggestions for Pterostilbene supplements:
Jarrow Formulas Pterostilbene, Supports Cardiovascular & Neurologic Health
This supplement comes in a bottle with a count of 60 veggie capsules of 50 mg each. It was given four and a half stars as an average rating by all reviewers. The supplement contains only Pterostilbene and no other compounds or chemicals, which is fine.
However, it is also a little strange since the company expressed their belief that both Pterostilbene and Resveratrol complement each other very well.
It would have been nice to see a mix of both of these compounds together as they offer even better benefits when taken simultaneously.
They also strongly believe that Pterostilbene can help with heart health due to its ability to reduce oxidative stress and a properly modulated inflammatory response. According to research done in the past, this is correct. Pterostilbene can increase heart health when taken over time.
One of the reviewers stated that they were pleasantly surprised to see such immediate results. They complained that recently they had been experiencing numbness and tingling in their extremities whenever they would wake up after sleeping on their arm, suggesting poor blood circulation.
Within a few hours of taking the supplement, they started to feel more energetic and they were also more focused mentally. Furthermore, the next morning when they woke up, the numbness feeling in their arms was gone, they had more energy in the gym, and their overall mood was wonderful.
Another reviewer stated that the supplement is simply magic. They are 89 years old and have started to experience issues with balance and joint aches. Three days after taking Pterostilbene, their balance issues completely disappeared. Twenty days after starting to take the supplement the aches in their knees also went away.
Overall, we must say that this supplement really works and improves the lives of all who have taken it. Priced at $12.11 per bottle or $0.20 per dose, it is definitely worth giving a try to see if this supplement is right for you and the problems you might be experiencing.
Mental Refreshment: Pterostilbene
This company’s Pterostilbene supplement comes in a bottle of 180 capsules with 150mg of Pterostilbene per capsule. The reviewers of this product also gave it an average of four and a half stars out of five.
The company lists that the benefits of this product are “Supports Cardiovascular Health, Promotes Longevity and Healthy Ageing, Enhances Brain Heath and Function, Supports Normal Glucose Levels.”
Since we know a lot of information about Pterostilbene, we can conclude that all of this information is true. Another thing that was mentioned by the company was that this supplement is made in the USA, Florida to be precise. This bit of information might be useful for those who place a higher value on products made in the USA.
One of the reviewers who purchased this product states that they have been taking it for some time and have not seen any side-effects.
The bottle was very easy to open and there was no weird taste associated with the capsules. They also mentioned that they dropped the bottle by accident a few times but all the capsules remained intact and did not break open.
Another reviewer said that since they started taking this supplement, they have noticed more energy when doing things that used to tire them out very quickly. Furthermore, situations that usually promoted stress and anxiety are now dealt with more calmly due to the influence of the supplement.
Although the dosage of this supplement is higher by 100mg then the previous one, we don’t see any issue with taking 150mb instead of the suggested 50mg.
The price is a bit higher, but this is also due to the fact that each bottle has three times the number of capsules inside than the previous supplement. One bottle of Mental Refreshment: Pterostilbene will cost you $29.99, which is equivalent to $0.17 per capsule.
The only thing we did not like about the reviews of this product is that some of them mentioned that “This product was provided at a discounted price in exchange for my honest review”. This doesn’t really mean the reviews cannot be relied on but should be considered when purchasing this specific brand of supplement.
Pterostilbene Longevity and Antioxidant Supplement from Absorb Health
This is another independent Pterostilbene supplement. This company claims that Pterostilbene is four times more powerful than Resveratrol, which technically is correct since Pterostilbene is four more times bioavailable than Resveratrol.
This supplement also seems to offer the same benefits as the other ones we have listed prior. It comes in a bottle of 100 capsules at 100mg per capsule. This company offers free shipping on all orders over $25, as well as a money back guarantee on all orders. This is a nice cushion in case you determine that Pterostilbene is not for you.
The first review we read stated that the company was fantastic and that the person had ordered many products from them before ordering Pterostilbene and orders always arrived within a few days.
This reviewer also measured their c-reactive protein levels prior to taking the supplement and then a few days afterward, and the results showed a great decrease in the protein levels. C-reactive protein measures general levels of inflammation in your body.
Another reviewer stated that they noticed the effects of Pterostilbene immediately via the amounts of energy they had available throughout their daily activities. They also noted that after taking this supplement for a few weeks, their skin started to look and feel better as well. Finally, they also mentioned that the price was a steal compared to many other products.
Out of all the reviews we read regarding this supplement, only three were negative out of nearly one hundred. Considering the possibility of shipping mishaps or Pterostilbene not having the same effect on some people as others, 3% negative reviews is completely acceptable in our opinions.
The cost of this supplement is $22.99 per bottle, which ends up being $0.22 per capsule. While this is the highest priced supplement we have talked about today, it is still pretty low and acceptable if you want to try this product out.
The only thing we should mention is that Pterostilbene Longevity and Antioxidant Supplement from Absorb Health contains maltodextrin, which has a high glycemic index. This means that if you are a diabetic you should be careful with the impact that this supplement can have on your glucose levels.
Now Foods Pterostilbene and Resveratrol
Last but certainly not least, we have the Pterostilbene and Resveratrol supplement by Now Foods. This is the only supplement on our list that has a combination of both Pterostilbene and Resveratrol. In our opinion, this is the best way to utilize both of these compounds to increase your mental and physical health and prolong your lifespan.
Each bottle contains 60 veggie capsules, each containing 50mg of Pterostilbene and 250mg of natural Resveratrol. The dosage of Pterostilbene is right on the spot, but the dosage for Resveratrol seems a little high. Resveratrol can have unwanted laxative like side-effects, so be careful when using this supplement.
Now Foods does mention that pterostilbene is a naturally occurring polyphenol that is closely related to resveratrol, which is definitely true although they function slightly differently. They also point out that pterostilbene is easier to absorb by the body, which is also true because of the bioavailability of pterostilbene.
Their first reviewer stated that they have been taking the supplement for a month and that it work great. They stated that they were 80 years old and since taking the supplement their arthritis pain has drastically decreased.
They also mentioned that their brain seems to function better. This customer was very happy with the results of this product and feels that paying $1 per day is a trivial price to pay to “BE” better.
There have been many other reviews that stated the reputation of the brand is top notch and the product left them feeling great.
A few people wrote that the supplement is causing a laxative like side-effect, which is anticipated due to the higher than suggested dosage of Resveratrol. While this side-effect might not surface in most consumers, it is a possibility and should be taken into account.
Overall, the combination of both Pterostilbene and Resveratrol makes this product a good choice. While is significantly higher priced than the other items we listed today at $26.71 per bottle and $0.45 per capsule, the reason for this is because two different compounds are included.
The only issue we have with this product is the possibility of the laxative like side-effects, which might be a big deal for some people. Regardless, this is the best choice for those looking to reap the benefits of both Pterostilbene and Resveratrol in one pill.
Pterostilbene Review Summary
Pterostilbene can do wonders for your body and your mind. There has been plenty of scientific research done to prove this, but you also have to keep in mind that all chemical and natural elements will affect each body in a different way.
So, even though this fantastic compound works miracles for so many people, this does not necessarily mean it will do the same for you. Although it is very likely that you will end up enjoying the benefits of Pterostilbene, you have to keep in mind that you might not experience all of these benefits.
Luckily, these supplements aren’t too expensive and are definitely worth trying out to see what you can gain from them. Make your choice from among the supplements we listed and you will surely be part of the majority of people who have nothing but good things to say about Pterostilbene.