What Is Chondroitin?
Chondroitin is a biological polymer that functions as a connecting matrix in the protein filament that is found in the cartilage.
Chondroitin can be obtained from animals, most commonly in shark and bovine cartilage. The biological polymer can also be manufactured from a lab using various biological methods. Chondroitin is usually available as a salt of sulfate.
The Mechanism Of Action Of Chondroitin
The biological polymer is a cartilage derivative. It is a component of the bone cartilage. When it is administered, it acts by repairing the cartilage and reducing the inflammation in the synovial joint.
Uses Of Chondroitin In Osteoarthritis
Chondroitin is indicated for the management of osteoarthritis, which is a musculoskeletal disease. Osteoarthritis involves the degradation of the cartilage that is found in the synovial joints in the body.
The biological polymer plays a significant role in the formation of new cartilage in the body. Research has shown that chondroitin stimulates the formation of proteoglycan.
Proteoglycan is one of the substances that are required for the synthesis of a new cartilage matrix. The use of chondroitin in the management of osteoarthritis has gained popularity due to its accelerated healing process.
The Recommended Dose Of Chondroitin Sulfate
Chondroitin polymer can be administered orally for the management of osteoarthritis at a dose that ranges between 800mg to 1200mg.
Positive results of the treatment will manifest after several months of treatment. The supplement is also available as an ointment or cream that is applied on the skin by people with osteoarthritis.
The product is also available as an eye drop that is used in the management of dry eyes and also during cataract surgery.
No available literature explains the adverse effects that may result from an overdose of chondroitin supplements. The European League against Rheumatism (EULAR) recommends the drug as one of the safest against osteoarthritis.
The drug is not metabolized by the CYP450 enzymes in the body, hence reducing any chances of drug interactions when administered with another drug. Information about the drug's safety in pregnant and lactating mothers is also not available.
What Is Glucosamine?
Glucosamine is a natural component that is found in the human body. However, it is therapeutically available in the form of a hydrochloride and in sulfate salts. The supplement is also available in the form of N-acetyl glucosamine.
The materials used in the manufacture of glucosamine supplements have been derived from chitin which is extracted from shellfish. Advancement in technology has seen the natural supplement being obtained from vegetables through fermentation.
Use Of Glucosamine In Osteoarthritis
Glucosamine plays a crucial role in the body. It is involved in the synthesis of glycosaminoglycan and glycoproteins which act as the building blocks in the formation of new cartilage. Degradation of the cartilage contributes to the development and progress of osteoarthritis.
The Mechanism Of Action Of Glucosamine
The supplement is an amino acid and an important precursor in the synthesis of glycosylated proteins and lipids. Supplemental glucosamine is involved in the synthesis of a new cartilage since it is a precursor of glycosaminoglycan.
The Recommended Dose Of Glucosamine
The typical dose of glucosamine for individuals suffering from osteoarthritis is 500mg taken three times a day. Medical personnel advise that the supplement should be taken with meals to prevent a stomach upset.
Risks Of Taking Glucosamine
Adverse effects that result from the use of this nutritional supplement are mild and rare. One is likely to experience them if they take an overdose of the dietary supplement.
Common side effects include heartburn, drowsiness, headaches, and stomach upset. Allergic individuals should be cautious when using this nutritional supplement.
People who have chronic illnesses like diabetes, kidney disease, and bleeding disorders should consult with their doctors before taking the medication. No literature explains the supplement's safety in pregnant and breastfeeding mothers.
Glucosamine And Chondroitin Combination For Osteoarthritis
Studies have shown that glucosamine and chondroitin combination is more effective than taking either of the supplements alone.
Individuals who suffer from an acute osteoarthritis are more likely to benefit from the glucosamine chondroitin combination than those whose condition has advanced.
A study on the combination therapy, named the Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT), found out that the combination of the two supplements showed significant relief in individuals having moderate to severe pain. The study also found that the combination of the two supplements worked well in preventing joint damage in the knees.
Top Products That Contain Glucosamine and Chondroitin
1. Doctor's Best Glucosamine/Chondroitin/MSM
This product features OptiMSM. It supports the function of the joint structure as well as the formation of new cartilage. The product features three primary active ingredients that are responsible for its activities.
Each serving of the product has 750mg of glucosamine sulfate, 600mg of chondroitin sulfate, and 500mg of MSM. The product is sold at $19.66. Customers claim that the pain they felt subsided after using the product.
2. Move Free Glucosamine Chondroitin MSM and Hyaluronic Acid Joint Supplement
This product supports functions of the joint structure. It provides lubrication, mobility, and comfort to the joint. It also protects the joint tissue.
Hyaluronic acid gets absorbed into joints, providing cushioning to the joint structure. This product is sold at $15.82 for a bottle of 120 coated tablets.
3. Kirkland Signature Extra Strength Glucosamine
The active chemicals in this product include glucosamine hydrochloride 1500mg and MSM 1500mg. The MSM is a bioavailable sulfur which is a necessity.
The sulfur works in combination with glucosamine in the synthesis of the cartilage tissue. A bottle of 375 tablets is sold for $19. Customers have rated this product highly due to its effectiveness.
It is the best pain reliever for most individuals suffering from osteoarthritis.
4. Osteo Bi-Flex Triple Strength
This product is available in packets of 120 coated tablets for $17.69. The active ingredients in this product include joint shield, chondroitin, and glucosamine. Its users claim that the drug works well in relieving joint pains.
Conclusion
Various studies support the use of glucosamine and chondroitin in the management of osteoarthritis. However, no sufficient data explains the possible adverse effects of these supplements, especially in special populations.
It is important to consult a doctor or a pharmacist before administering these supplements to the special populations including pregnant and breastfeeding women.
