Spermidine Review – Good For You?

As you browse through anti-aging products on the market, one of the most noticeable features of most products is the exhaustive list of ingredients. The best way to determine whether you have an active and powerful ingredient behind those anti-aging properties is to actually understand the ingredient’s impact and driving mechanisms.

Obviously, as a consumer, performing research on every ingredient that goes into an anti-aging product is just not feasible. Moreover, it is not something that you should have to do. However, if you are interested in at least being able to recognize quality ingredients from an exhaustive list, the one ingredient that you should be looking for is Spermidine.

What is Spermidine?

Spermidine, as you may have already inferred, originates from semen – among other living tissues and ribosomes in the body. Researchers have isolated the active compound and determined its anti-aging properties through a number of studies. In addition to isolating spermidine from semen, it is also a naturally occurring compound known as a polyamine. A polyamine is an organic compound that has two or more amino groups, a low cellular level. As a result, there are a number of useful health benefits to be derived from the compound, one of the most prominent and well-recognized benefits being that it acts as a longevity mechanism in mammals because of a number of various action mechanisms.

Since spermidine is not being reviewed in a product, but as an ingredient on its own, much of this review is going to focus on the studies performed. Moreover, it will also cover information relative to anti-aging and non-anti-aging properties. This way, you get the most important benefit of this review, which is to determine how spermidine performs in your anti-aging products and leads to positive and long-term health benefits for you and your appearance.

Gerontology: The Molecular Basis of Anti-aging Effects of Spermidine

There are many prominent studies on the market, but one of the most pertinent is by the School of Biology in the United Kingdom. In this study, researchers reviewed the multifaceted process of cellular aging and how exposure to chronic inflammation, cellular stress, cell revival rates, and dysregulation of lipid metabolism affects the aging process adversely.

Here, researchers assessed the impact of spermidine to reduce the factors that lend themselves to the cellular aging process. During the research stage, it was found that since spermidine is a polyamine, it interacts with negatively charged molecules like RNA, DNA, and lipids. With the ability to bind to varying molecules, the spermidine is able to promote cell growth, stability of DNA, and cell proliferation in the body. The final result is that with such control over so many cellular functions, spermidine is able to set back the aging process.

The research found that the aging process is slowed down and cells are repaired to a more youthful function in the following ways:

Reduction of Inflammation

Cellular inflammation leads to cell damage that can promote age-related diseases. The more inflammation at the cellular level your body has, the higher the chance that your cells are being destroyed and are contributing to a more haggard and aged appearance. To combat the aging impact of inflammation, researchers found that polyamines, spermidine more specifically, are able to treat the microglial cells that are the primary drivers of inflammation. Since spermidine targets the source of inflammation, you protect your cells and attain a more youthful appearance.

Cell Growth

Another popular mechanism that lends itself to the anti-aging process is cellular growth spurred by spermidine. When cell growth is unregulated, tissue is able to regenerate at a rapid level, leading to smoother and more youthful looking skin. The research has shown that spermidine levels decline as you age. To prevent this from occurring, you can use anti-aging cosmetics that uses spermidine. With the additional infusion of spermidine, cellular growth can proliferate, leading to anti-aging properties.

The research study was just one of my that assessed the impact of spermidine. Overall, from this study, there is support that spermidine promotes anti-aging properties by preventing inflammation that leads to aging and by also promoting cellular growth, which repairs cells.

Nature Cell Biology: Spermidine Surprise for a Long Life

The second notable study performed was by a researcher at the University of Washington, Seattle at the Department of Pathology. The searcher’s published study identified therapies that mitigate the aging process and any age-associated disease. Unlike the previous study, the researcher observed how spermidine impacts the lifespan of yeast and how that impacts chromatin-mediated regulation of gene expression.

When treated with spermidine, the yeast’s cells experienced lower oxidative stress levels. In turn, the cells were able to rejuvenate faster, they experienced less inflammation, and they also proliferated at a higher rate in the substance. As a result, the spermidine treatment led to a longer lifespan for the yeast. In addition to studying the impact of spermidine on yeast, researchers also examined its impact in worms, flies, and other insects and found that it leads to similar results.

While it may seem off-putting to cite a study that was performed on non-human cells, the purpose in doing so is to highlight that spermidine’s impact is universal. Not only do human cells experience growth, reduced inflammation, and ultimate longevity from spermidine, but so do many other aspects of nature. This further supports the contention that spermidine is a wholly effective ingredient that is added to today’s anti-aging products.

Summary

As a consumer, it is imperative to be aware of what you are buying. By choosing products that you can rely upon and that support your ultimate end goals, you can ensure that you are smartly investing your funds and most importantly, that you are not sorely disappointed when purchasing and trying out a product.

When choosing an anti-aging product, spermidine is always a positive ingredient to look into if one of your end goals is to generate anti-aging benefits. While there are not yet many products on the market that feature spermidine, growth is expected in the next few years.